Literature DB >> 16085919

Patterns of CD8 T-cell epitopes within the human papillomavirus type 16 (HPV 16) E6 protein among young women whose HPV 16 infection has become undetectable.

Mayumi Nakagawa1, Kevin H Kim, Anna-Barbara Moscicki.   

Abstract

The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined. T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus. Evidence of potential antigenic epitopes was shown in 8 of 23 (34.8%) women.

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Year:  2005        PMID: 16085919      PMCID: PMC1182184          DOI: 10.1128/CDLI.12.8.1003-1005.2005

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN: 1071-412X


  7 in total

1.  Amplification of low-frequency antiviral CD8 T cell responses using autologous dendritic cells.

Authors:  Marie Larsson; David T Wilkens; Jean-François Fonteneau; Thomas J Beadle; Melissa J Merritt; Rhonda G Kost; Patrick A J Haslett; Susan Cu-Uvin; Nina Bhardwaj; Douglas F Nixon; Barbara L Shacklett
Journal:  AIDS       Date:  2002-01-25       Impact factor: 4.177

Review 2.  Papillomavirus infections--a major cause of human cancers.

Authors:  H zur Hausen
Journal:  Biochim Biophys Acta       Date:  1996-10-09

3.  CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects.

Authors:  R Kaul; T Dong; F A Plummer; J Kimani; T Rostron; P Kiama; E Njagi; E Irungu; B Farah; J Oyugi; R Chakraborty; K S MacDonald; J J Bwayo; A McMichael; S L Rowland-Jones
Journal:  J Clin Invest       Date:  2001-05       Impact factor: 14.808

4.  Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens.

Authors:  M Nakagawa; D P Stites; S Patel; S Farhat; M Scott; N K Hills; J M Palefsky; A B Moscicki
Journal:  J Infect Dis       Date:  2000-07-28       Impact factor: 5.226

5.  The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women.

Authors:  A B Moscicki; S Shiboski; J Broering; K Powell; L Clayton; N Jay; T M Darragh; R Brescia; S Kanowitz; S B Miller; J Stone; E Hanson; J Palefsky
Journal:  J Pediatr       Date:  1998-02       Impact factor: 4.406

6.  Spontaneous regression of grade 3 vulvar intraepithelial neoplasia associated with human papillomavirus-16-specific CD4(+) and CD8(+) T-cell responses.

Authors:  Isabelle Bourgault Villada; Micheline Moyal Barracco; Isabelle Bourgault Villada; Micheline Moyal Barracco; Marianne Ziol; Aude Chaboissier; Nathalie Barget; Sophie Berville; Bernard Paniel; Eric Jullian; Thierry Clerici; Bernard Maillère; Jean Gérard Guillet
Journal:  Cancer Res       Date:  2004-12-01       Impact factor: 12.701

7.  Different methods of identifying new antigenic epitopes of human papillomavirus type 16 E6 and E7 proteins.

Authors:  Mayumi Nakagawa; Kevin H Kim; Anna-Barbara Moscicki
Journal:  Clin Diagn Lab Immunol       Date:  2004-09
  7 in total
  13 in total

1.  Use of interferon-γ enzyme-linked immunospot assay to characterize novel T-cell epitopes of human papillomavirus.

Authors:  Xuelian Wang; William W Greenfield; Hannah N Coleman; Lindsey E James; Mayumi Nakagawa
Journal:  J Vis Exp       Date:  2012-03-08       Impact factor: 1.355

2.  A Human Papillomavirus Type 16 E6 52-62 CD4 T-Cell Epitope Restricted by the HLA-DR11 Molecule Described in an Epitope Hotspot.

Authors:  Hannah N Coleman; Xuelian Wang; William W Greenfield; Mayumi Nakagawa
Journal:  MOJ Immunol       Date:  2014

3.  Biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response?

Authors:  Erin M Siegel; Nitin Patel; Beibei Lu; Ji-Hyun Lee; Alan G Nyitray; Neal E Craft; Krystyna Frenkel; Luisa L Villa; Eduardo L Franco; Anna R Giuliano
Journal:  Int J Cancer       Date:  2011-11-28       Impact factor: 7.396

4.  CD4+ T-cell response against human papillomavirus type 16 E6 protein is associated with a favorable clinical trend.

Authors:  Kevin H Kim; William W Greenfield; Martin J Cannon; Hannah N Coleman; Horace J Spencer; Mayumi Nakagawa
Journal:  Cancer Immunol Immunother       Date:  2011-08-13       Impact factor: 6.968

5.  HLA class I binding promiscuity of the CD8 T-cell epitopes of human papillomavirus type 16 E6 protein.

Authors:  Mayumi Nakagawa; Kevin H Kim; Tiffany M Gillam; Anna-Barbara Moscicki
Journal:  J Virol       Date:  2006-11-15       Impact factor: 5.103

6.  Detection of human papillomavirus type 16-specific T lymphocytes by a recombinant vaccinia virus-based enzyme-linked immunospot assay.

Authors:  Kevin H Kim; William Greenfield; Ezekiel Shotts; Mayumi Nakagawa
Journal:  Clin Vaccine Immunol       Date:  2007-02-21

7.  Human papillomavirus 16-specific T cell responses in classic HPV-related vulvar intra-epithelial neoplasia. Determination of strongly immunogenic regions from E6 and E7 proteins.

Authors:  I Bourgault Villada; M Moyal Barracco; S Berville; M L Bafounta; C Longvert; V Prémel; P Villefroy; E Jullian; T Clerici; B Paniel; B Maillère; J Choppin; J G Guillet
Journal:  Clin Exp Immunol       Date:  2009-07-30       Impact factor: 4.330

8.  Memory T cells specific for novel human papillomavirus type 16 (HPV16) E6 epitopes in women whose HPV16 infection has become undetectable.

Authors:  Xuelian Wang; Anna-Barbara Moscicki; Laura Tsang; Andrea Brockman; Mayumi Nakagawa
Journal:  Clin Vaccine Immunol       Date:  2008-04-30

9.  A novel CD4 T-cell epitope described from one of the cervical cancer patients vaccinated with HPV 16 or 18 E7-pulsed dendritic cells.

Authors:  Xuelian Wang; Alessandro D Santin; Stefania Bellone; Sushil Gupta; Mayumi Nakagawa
Journal:  Cancer Immunol Immunother       Date:  2008-04-30       Impact factor: 6.968

10.  A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine with Candida skin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3.

Authors:  William W Greenfield; Shawna L Stratton; Rebecca S Myrick; Rita Vaughn; Lisa M Donnalley; Hannah N Coleman; Maria Mercado; Andrea M Moerman-Herzog; Horace J Spencer; Nancy R Andrews-Collins; Wilbur C Hitt; Gordon M Low; Nirvana A Manning; Samantha S McKelvey; Dora Smith; Michael V Smith; Amy M Phillips; C Matthew Quick; Susanne K Jeffus; Laura F Hutchins; Mayumi Nakagawa
Journal:  Oncoimmunology       Date:  2015-05-27       Impact factor: 8.110

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