OBJECTIVE: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. METHODS: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). RESULTS: Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. CONCLUSION: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
OBJECTIVE: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. METHODS: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). RESULTS: Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. CONCLUSION: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
Authors: Edward McAuley; Amanda N Szabo; Emily L Mailey; Kirk I Erickson; Michelle Voss; Siobhan M White; Thomas R Wójcicki; Neha Gothe; Erin A Olson; Sean P Mullen; Arthur F Kramer Journal: Ment Health Phys Act Date: 2011-06-01
Authors: Michael Crowe; Ross Andel; Virginia Wadley; Sarah Cook; Frederick Unverzagt; Michael Marsiske; Karlene Ball Journal: Int J Geriatr Psychiatry Date: 2006-12 Impact factor: 3.485
Authors: Amanda N Szabo; Edward McAuley; Kirk I Erickson; Michelle Voss; Ruchika S Prakash; Emily L Mailey; Thomas R Wójcicki; Siobhan M White; Neha Gothe; Erin A Olson; Arthur F Kramer Journal: Neuropsychology Date: 2011-09 Impact factor: 3.295
Authors: Sarah E Cook; Michael Marsiske; Kelsey R Thomas; Frederick W Unverzagt; Virginia G Wadley; Jessica B S Langbaum; Michael Crowe Journal: J Int Neuropsychol Soc Date: 2012-10-25 Impact factor: 2.892