Literature DB >> 16085622

Long-term persistence of disability following severe lower-limb trauma. Results of a seven-year follow-up.

Ellen J MacKenzie1, Michael J Bosse, Andrew N Pollak, Lawrence X Webb, Marc F Swiontkowski, James F Kellam, Douglas G Smith, Roy W Sanders, Alan L Jones, Adam J Starr, Mark P McAndrew, Brendan M Patterson, Andrew R Burgess, Renan C Castillo.   

Abstract

BACKGROUND: A recent study demonstrated that patients treated with amputation and those treated with reconstruction had comparable functional outcomes at two years following limb-threatening trauma. The present study was designed to determine whether those outcomes improved after two years, and whether differences according to the type of treatment emerged.
METHODS: Three hundred and ninety-seven patients who had undergone amputation or reconstruction of the lower extremity were interviewed by telephone at an average of eighty-four months after the injury. Functional outcomes were assessed with use of the physical and psychosocial subscores of the Sickness Impact Profile (SIP) and were compared with similar scores obtained at twenty-four months.
RESULTS: On the average, physical and psychosocial functioning deteriorated between twenty-four and eighty-four months after the injury. At eighty-four months, one-half of the patients had a physical SIP subscore of > or = 10 points, which is indicative of substantial disability, and only 34.5% had a score typical of a general population of similar age and gender. There were few significant differences in the outcomes according to the type of treatment, with two exceptions. Compared with patients treated with reconstruction for a tibial shaft fracture, those with only a severe soft-tissue injury of the leg were 3.1 times more likely to have a physical SIP subscore of 5 points (p < 0.05) and those treated with a through-the-knee amputation were 11.5 times more likely to have a physical subscore of 5 points (p < 0.05). There were no significant differences in the psychosocial outcomes according to treatment group. Patient characteristics that were significantly associated with poorer outcomes included older age, female gender, nonwhite race, lower education level, living in a poor household, current or previous smoking, low self-efficacy, poor self-reported health status before the injury, and involvement with the legal system in an effort to obtain disability payments. Except for age, predictors of poor outcome were similar at twenty-four and eighty-four months after the injury.
CONCLUSIONS: The results confirm previous conclusions that reconstruction for the treatment of injuries below the distal part of the femur typically results in functional outcomes equivalent to those of amputation. Regardless of the treatment option, however, long-term functional outcomes are poor. Priority should be given to efforts to improve post-acute-care services that address secondary conditions that compromise optimal recovery.

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Year:  2005        PMID: 16085622     DOI: 10.2106/JBJS.E.00032

Source DB:  PubMed          Journal:  J Bone Joint Surg Am        ISSN: 0021-9355            Impact factor:   5.284


  68 in total

Review 1.  A systematic review of outcomes and complications of reconstruction and amputation for type IIIB and IIIC fractures of the tibia.

Authors:  Daniel Saddawi-Konefka; Hyungjin Myra Kim; Kevin C Chung
Journal:  Plast Reconstr Surg       Date:  2008-12       Impact factor: 4.730

2.  Proximal tibial metaphyseal fractures with severe soft tissue injury: clinical and functional results at 2 years.

Authors:  James S Starman; Renan C Castillo; Michael J Bosse; Ellen J MacKenzie
Journal:  Clin Orthop Relat Res       Date:  2009-10-28       Impact factor: 4.176

3.  Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma.

Authors:  Renan C Castillo; Yanjie Huang; Daniel Scharfstein; Katherine Frey; Michael J Bosse; Andrew N Pollak; Heather A Vallier; Kristin R Archer; Robert A Hymes; Anna B Newcomb; Ellen J MacKenzie; Stephen Wegener; Joseph R Hsu; Madhav A Karunakar; Rachel B Seymour; Stephen H Sims; Eileen Flores; Christine Churchill; David J Hak; Corey E Henderson; Hassan R Mir; Daniel S Chan; Anjan R Shah; Barbara Steverson; Jerald Westberg; Joshua L Gary; Timothy S Achor; Andrew Choo; John W Munz; Melissa Porrey; Sarah Hendrickson; Mary A Breslin; Todd O McKinley; Greg E Gaski; Laurence B Kempton; Anthony T Sorkin; Walter W Virkus; Lauren C Hill; Clifford B Jones; Debra L Sietsema; Robert V O'Toole; Katherine Ordonio; Andrea L Howe; Timothy J Zerhusen; William Obremskey; Robert H Boyce; A Alex Jahangir; Cesar S Molina; Manish K Sethi; Susan W Vanston; Eben A Carroll; Danielle Yemiola Drye; Martha B Holden; Susan C Collins; Elizabeth Wysocki
Journal:  JAMA Surg       Date:  2019-02-20       Impact factor: 14.766

4.  BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma.

Authors:  Casey E Vantucci; Laxminarayanan Krishan; Albert Cheng; Ayanna Prather; Krishnendu Roy; Robert E Guldberg
Journal:  Biomater Sci       Date:  2021-03-10       Impact factor: 6.843

5.  ECONOMIC EVALUATIONS OF INTERVENTIONS FOR TRANSTIBIAL AMPUTEES: A SCOPING REVIEW OF COMPARATIVE STUDIES.

Authors:  M Jason Highsmith; Jason T Kahle; Amanda Lewandowski; Tyler D Klenow; John J Orriola; Rebecca M Miro; Owen T Hill; Sylvia Ursula Raschke; Michael S Orendurff; James T Highsmith; Bryce S Sutton
Journal:  Technol Innov       Date:  2016-09-01

Review 6.  Regenerative and Rehabilitative Medicine: A Necessary Synergy for Functional Recovery from Volumetric Muscle Loss Injury.

Authors:  Sarah M Greising; Christopher L Dearth; Benjamin T Corona
Journal:  Cells Tissues Organs       Date:  2016-11-09       Impact factor: 2.481

7.  Functional analysis of limb recovery following autograft treatment of volumetric muscle loss in the quadriceps femoris.

Authors:  Mon Tzu A Li; Nick J Willett; Brent A Uhrig; Robert E Guldberg; Gordon L Warren
Journal:  J Biomech       Date:  2013-11-11       Impact factor: 2.712

8.  A cost-utility analysis of amputation versus salvage for Gustilo type IIIB and IIIC open tibial fractures.

Authors:  Kevin C Chung; Daniel Saddawi-Konefka; Steven C Haase; Gautam Kaul
Journal:  Plast Reconstr Surg       Date:  2009-12       Impact factor: 4.730

9.  Psychosocial Factors Predict Pain and Physical Health After Lower Extremity Trauma.

Authors:  Kristin R Archer; Christine M Abraham; William T Obremskey
Journal:  Clin Orthop Relat Res       Date:  2015-11       Impact factor: 4.176

Review 10.  [Medication and bone metabolism: Clinical importance for fracture treatment].

Authors:  F Barvencik
Journal:  Unfallchirurg       Date:  2015-12       Impact factor: 1.000

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