| Literature DB >> 16084743 |
Ben Steventon1, Carlos Carmona-Fontaine, Roberto Mayor.
Abstract
The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.Entities:
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Year: 2005 PMID: 16084743 DOI: 10.1016/j.semcdb.2005.06.001
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN: 1084-9521 Impact factor: 7.727