Literature DB >> 16084727

Water-soluble chitosan derivatives as a BACE1 inhibitor.

Jae-Young Je1, Se-Kwon Kim.   

Abstract

BACE1 (the beta-site APP-cleaving enzyme) inhibitory activities of water-soluble chitosan derivatives substituted with aminoethyl, dimethylaminoethyl and diethylaminoethyl groups were investigated. AE-chitosan (90%) prepared from 90% deacetylated chitosan showed the strongest BACE1 inhibitory activity than those of other derivatives. The inhibitory pattern was found to be non-competitive by Dixon plot, and the value of the inhibition constant (K(i)) was 85 microg/mL.

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Year:  2005        PMID： 16084727     DOI： 10.1016/j.bmc.2005.07.004

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


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