| Literature DB >> 16084694 |
Vaiva Petrenaite1, Anne Sabers, Jacob Hansen-Schwartz.
Abstract
Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.Entities:
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Year: 2005 PMID： 16084694 DOI： 10.1016/j.eplepsyres.2005.06.004
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045