| Literature DB >> 16084101 |
Nils Sunder-Plassmann1, Vasiliki Sarli, Michael Gartner, Mathias Utz, Jeanette Seiler, Stefan Huemmer, Thomas U Mayer, Thomas Surrey, Athanassios Giannis.
Abstract
The mitotic kinesin Eg5 (or KSP) is a crucial player in the development and function of the mitotic spindle. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering with other microtubule-dependent processes. Therefore, it is a potential target in cancer therapy. Here, we report the synthesis and biological evaluation of a small library of molecules based on the structure of the known Eg5 inhibitor HR22C16. One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor.Entities:
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Year: 2005 PMID： 16084101 DOI： 10.1016/j.bmc.2005.06.027
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641