BACKGROUND AND PURPOSE: Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic. METHODS: We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model. RESULTS: Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P=0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24). CONCLUSIONS: In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.
BACKGROUND AND PURPOSE:Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic. METHODS: We screened 305 consecutive cardiopathypatients. Significant predictors of stroke in univariable analyses were included in a multivariable model. RESULTS:Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P=0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24). CONCLUSIONS: In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.
Authors: Vinícius Viana Abreu Montanaro; Thiago Falcão Hora; Creuza Maria da Silva; Carla Verônica de Viana Santos; Maria Inacia Ruas Lima; Eleonora Maria de Jesus Oliveira; Gabriel R de Freitas Journal: Neurol Sci Date: 2019-07-30 Impact factor: 3.307
Authors: Jamary Oliveira-Filho; Ana C P Ornellas; Cathy R Zhang; Luciana M B Oliveira; Théo Araújo-Santos; Valeria M Borges; Laís M G B Ventura; Francisco J F B Reis; Roque Aras; André M Fernandes; Jonathan Rosand; Steven M Greenberg; Karen L Furie; Natalia S Rost Journal: J Stroke Cerebrovasc Dis Date: 2015-05-06 Impact factor: 2.136
Authors: Vinícius Viana Abreu Montanaro; Creuza Maria da Silva; Carla Verônica de Viana Santos; Maria Inacia Ruas Lima; Edson Marcio Negrão; Gabriel R de Freitas Journal: J Neurol Date: 2016-09-13 Impact factor: 4.849
Authors: Gisele Sampaio Silva; Nelson J Maldonado; Jorge H Mejia-Mantilla; Santiago Ortega-Gutierrez; Jan Claassen; Panayiotis Varelas; Jose I Suarez Journal: Neurocrit Care Date: 2019-12 Impact factor: 3.210