The significance of mammotome core biopsy specimens without radiographically identifiable microcalcification and their influence on surgical management--a retrospective review with histological correlation.

The aim of this study is to assess core specimens which do not contain radiographically visible calcification at stereotactic vacuum assisted core biopsy (SVACB) of indeterminate microcalcification, to determine what influence they may have on the surgical management of patients with breast disease. Review was made of the core biopsy and surgical histology results of 104 SVACB biopsies of indeterminate microcalcification over a 26 month period. Cores were placed in separate pots; POT A for cores containing microcalcification and POT B for cores without radiographically visible microcalcification before being sent to histology. Of 104 biopsies, 25% contained B3-B5 pathology in POT B and at surgery this correlated with a higher grade of ductal carcinoma in situ (DCIS) and an increased likelihood of invasive disease. The presence of B3-B5 pathology in POT B itself however did not act as a strong indicator of radiological-histological size discrepancy in this study.