Literature DB >> 16081070

STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.

Wai-Ho Yap1, Elizabeth Yeoh, Alice Tay, Sydney Brenner, Byrappa Venkatesh.   

Abstract

STAT4 is a transcription factor activated in response to IL-12, and is involved in Th1 cell development. The molecular mechanisms controlling the transcription of the STAT4 gene are however, unclear. Sequence comparison of the 5' flanking regions of human, mouse and pufferfish (Fugu rubripes) Stat4 genes revealed a high frequency of Ikaros (Ik) binding elements in all three species. We then investigated the role of Ik binding elements in the human STAT4 promoter using Jurkat T cells. Transactivation, electrophoretic mobility shift assay and RNA interference-mediated gene knockdown experiments revealed that Ik is involved in the regulation of STAT4 in human T cells.

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Year:  2005        PMID： 16081070     DOI： 10.1016/j.febslet.2005.07.018

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

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