| Literature DB >> 16078856 |
Cecilia Bombelli1, Francesca Faggioli, Paola Luciani, Giovanna Mancini, Maria Grazia Sacco.
Abstract
Cationic liposomes formulated with neutral 1,2-dimyristoyl-sn-glycero-3-phosphocholine and cationic gemini surfactants were used for transfecting different cell lines with a reporter gene. The efficiency in the transfection has been correlated to the high extent of DNA condensation observed by circular dichroism, condensation shown to depend heavily on the gemini spacer structure. Transfection efficiency was better than that obtained with a commercial lipofection kit.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16078856 DOI： 10.1021/jm050477r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446