R Sehra1, K Underwood2. 1. Loma Linda University, c/o 13546 Mango Drive, Del Mar, CA , 92014, USA. ruchir@earthlink.net. 2. University of Southern California School of Medicine, c/o 13546 Mango Drive, Del Mar, CA , 92014, USA.
Abstract
BACKGROUND: This study aimed to explore the effects of nesiritide in children awaiting cardiac transplantation. METHODS: At the discretion of the attending physician, nesiritide was added to standard therapy for seven children (median age, 11 months) and continued until clinical improvement or transplantation. Blood pressure and urine output data were compared with data from the day before nesiritide institution. Safety parameters were assessed throughout the study. RESULTS: Urine output increased from 2.6 to 3.6 ml/kg/h (p = 0.04). No significant blood pressure changes or adverse effects related to nesiritide were noted. CONCLUSION: Nesiritide may be safe and effective for children with severe heart failure.
BACKGROUND: This study aimed to explore the effects of nesiritide in children awaiting cardiac transplantation. METHODS: At the discretion of the attending physician, nesiritide was added to standard therapy for seven children (median age, 11 months) and continued until clinical improvement or transplantation. Blood pressure and urine output data were compared with data from the day before nesiritide institution. Safety parameters were assessed throughout the study. RESULTS: Urine output increased from 2.6 to 3.6 ml/kg/h (p = 0.04). No significant blood pressure changes or adverse effects related to nesiritide were noted. CONCLUSION: Nesiritide may be safe and effective for children with severe heart failure.
Authors: Javed Butler; Charles Emerman; W Frank Peacock; Vandana S Mathur; James B Young Journal: Nephrol Dial Transplant Date: 2004-02 Impact factor: 5.992
Authors: Nader Moazami; Ralph J Damiano; Marci S Bailey; Rachel L Hess; Jennifer S Lawton; Marc R Moon; Michael K Pasque Journal: Ann Thorac Surg Date: 2003-06 Impact factor: 4.330