Literature DB >> 16076011

Decrease of serotonin transporters in blood platelets after epileptic seizures.

Aroldo Cupello1, Emilio Favale, Daniela Audenino, Simona Scarrone, Stefania Gastaldi, Claudio Albano.   

Abstract

Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.

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Year:  2005        PMID： 16076011     DOI： 10.1007/s11064-005-2676-2

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  13 in total

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3.  Binding of paroxetine to the serotonin transporter in membranes from different cells, subcellular fractions and species.

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4.  Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes.

Authors:  Aroldo Cupello; Daniela Audenino; Simona Scarrone; Michele Fornaro; Elena Gatta; Pantaleo Fornaro; Claudio Albano
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5.  Alzheimer disease and platelets: how's that relevant.

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  6 in total

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