Literature DB >> 16075376

Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism.

Walter J Lukiw1, Miguel Pappolla, Ricardo Palacios Pelaez, Nicolas G Bazan.   

Abstract

1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.

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Year:  2005        PMID： 16075376     DOI： 10.1007/s10571-005-4010-6

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  57 in total

Review 1.  Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease.

Authors:  Benjamin Wolozin
Journal:  Arch Neurol       Date:  2003-01

Review 2.  The role of 24S-hydroxycholesterol in Alzheimer's disease.

Authors:  H Kölsch; D Lütjohann; K von Bergmann; R Heun
Journal:  J Nutr Health Aging       Date:  2003       Impact factor: 4.075

3.  Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein.

Authors:  S Bodovitz; W L Klein
Journal:  J Biol Chem       Date:  1996-02-23       Impact factor: 5.157

4.  Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

Authors:  L M Refolo; B Malester; J LaFrancois; T Bryant-Thomas; R Wang; G S Tint; K Sambamurti; K Duff; M A Pappolla
Journal:  Neurobiol Dis       Date:  2000-08       Impact factor: 5.996

5.  Statins and the risk of dementia.

Authors:  H Jick; G L Zornberg; S S Jick; S Seshadri; D A Drachman
Journal:  Lancet       Date:  2000-11-11       Impact factor: 79.321

Review 6.  The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

Authors:  Stephen Howard Pasternak; John William Callahan; Don Joseph Mahuran
Journal:  J Alzheimers Dis       Date:  2004-02       Impact factor: 4.472

7.  Incidence and prevalence of dementia in the Cardiovascular Health Study.

Authors:  Annette L Fitzpatrick; Lewis H Kuller; Diane G Ives; Oscar L Lopez; William Jagust; John C S Breitner; Beverly Jones; Constantine Lyketsos; Corinne Dulberg
Journal:  J Am Geriatr Soc       Date:  2004-02       Impact factor: 5.562

Review 8.  Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease.

Authors:  Gjumrakch Aliev; Mark A Smith; Mark E Obrenovich; Jack C de la Torre; George Perry
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

9.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Authors:  W J Strittmatter; A M Saunders; D Schmechel; M Pericak-Vance; J Enghild; G S Salvesen; A D Roses
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

10.  Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.

Authors:  Victor L Marcheselli; Song Hong; Walter J Lukiw; Xiao Hua Tian; Karsten Gronert; Alberto Musto; Mattie Hardy; Juan M Gimenez; Nan Chiang; Charles N Serhan; Nicolas G Bazan
Journal:  J Biol Chem       Date:  2003-08-15       Impact factor: 5.157
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  17 in total

1.  Minocycline recovers MTT-formazan exocytosis impaired by amyloid beta peptide.

Authors:  Peter Kreutzmann; Gerald Wolf; Kathleen Kupsch
Journal:  Cell Mol Neurobiol       Date:  2010-05-09       Impact factor: 5.046

Review 2.  The effects of cholesterol on learning and memory.

Authors:  Bernard G Schreurs
Journal:  Neurosci Biobehav Rev       Date:  2010-05-12       Impact factor: 8.989

3.  Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions.

Authors:  Guruprasad R Pattar; Lixuan Tackett; Ping Liu; Jeffrey S Elmendorf
Journal:  Mutat Res       Date:  2006-07-25       Impact factor: 2.433

4.  Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD).

Authors:  Walter J Lukiw
Journal:  Expert Opin Emerg Drugs       Date:  2012-03-23       Impact factor: 4.191

5.  Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.

Authors:  S Snigdha; G Astarita; D Piomelli; C W Cotman
Journal:  Neuroscience       Date:  2011-12-13       Impact factor: 3.590

Review 6.  Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's disease.

Authors:  Yuhai Zhao; Jian-Guo Cui; Walter J Lukiw
Journal:  Mol Neurobiol       Date:  2006-12       Impact factor: 5.590

7.  Cardiovascular dementia - a different perspective.

Authors:  Udhaya Kumari; Klaus Heese
Journal:  Open Biochem J       Date:  2010-03-26

Review 8.  Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection.

Authors:  Nicolas G Bazan
Journal:  Mol Aspects Med       Date:  2018-10-01

9.  Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.

Authors:  Karen Assayag; Evgenia Yakunin; Virginie Loeb; Dennis J Selkoe; Ronit Sharon
Journal:  Am J Pathol       Date:  2007-11-30       Impact factor: 4.307

10.  Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer.

Authors:  Aileen I Pogue; Brandon M Jones; Surjyadipta Bhattacharjee; Maire E Percy; Yuhai Zhao; Walter J Lukiw
Journal:  Int J Mol Sci       Date:  2012-08-02       Impact factor: 6.208
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