Saad Hamdan Abdullah1, Koreaki Irie, Shizuo Oi. 1. Division of Pediatric Neurosurgery, Women's and Children's Medical Center, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, 105-8461 Tokyo, Japan.
Abstract
RATIONALE: Suprasellar tumors are common in the pediatric population and exhibit a wide range of pathological appearance and behavior. Although rare, pure suprasellar germinomas carry worse prognosis than other locations. METHODS: We present a case of a 10-year-old girl treated with therapeutic anticoagulation for previous cardiac valvular replacement, who presented with rapidly growing giant (>4 cm) suprasellar germinoma. Neoadjuvant chemotheraphy was effective and the dilated ventricles became slit-like. The fine free-hand maneuver using a fine rigid-rod neuroendoscope. "Oi-Samii Handy Pro" made it possible to obtain the tissue diagnosis. RESULTS: Complete remission was achieved using neoadjuvant chemotherapy, minimally invasive neuroendoscopic surgery, then followed by specific chemoradiotherapy. CONCLUSION: The role of neuroendoscopic procedure, performed in a difficult situation with normalized size of the ventricles, was emphasized.
RATIONALE: Suprasellar tumors are common in the pediatric population and exhibit a wide range of pathological appearance and behavior. Although rare, pure suprasellar germinomas carry worse prognosis than other locations. METHODS: We present a case of a 10-year-old girl treated with therapeutic anticoagulation for previous cardiac valvular replacement, who presented with rapidly growing giant (>4 cm) suprasellar germinoma. Neoadjuvant chemotheraphy was effective and the dilated ventricles became slit-like. The fine free-hand maneuver using a fine rigid-rod neuroendoscope. "Oi-Samii Handy Pro" made it possible to obtain the tissue diagnosis. RESULTS: Complete remission was achieved using neoadjuvant chemotherapy, minimally invasive neuroendoscopic surgery, then followed by specific chemoradiotherapy. CONCLUSION: The role of neuroendoscopic procedure, performed in a difficult situation with normalized size of the ventricles, was emphasized.
Authors: S Oi; M Shibata; J Tominaga; Y Honda; M Shinoda; F Takei; R Tsugane; K Matsuzawa; O Sato Journal: J Neurosurg Date: 2000-08 Impact factor: 5.115
Authors: S Janmohamed; A B Grossman; K Metcalfe; D G Lowe; D F Wood; S L Chew; J P Monson; G M Besser; P N Plowman Journal: Clin Endocrinol (Oxf) Date: 2002-10 Impact factor: 3.478