| Literature DB >> 16072039 |
Campbell W Gourlay1, Kathryn R Ayscough.
Abstract
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.Entities:
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Year: 2005 PMID： 16072039 DOI： 10.1038/nrm1682
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444