| Literature DB >> 1606341 |
C P Murphy1, E A Harden, J M Thompson.
Abstract
Two patients without prior histories of neurologic disorders experienced generalized seizures while receiving high-dose busulfan (total dose 16 mg/kg) as part of a preparative regimen for allogeneic bone marrow transplantation. A review of the literature revealed 14 similar occurrences. Maintenance of therapeutic blood concentrations of phenytoin in subsequent patients at our institution has resulted in no further patients experiencing generalized seizures. Prophylactic anticonvulsant therapy should be considered in patients receiving high doses of busulfan.Entities:
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Year: 1992 PMID： 1606341 DOI： 10.1177/106002809202600107
Source DB: PubMed Journal: Ann Pharmacother ISSN： 1060-0280 Impact factor: 3.154