| Literature DB >> 16061364 |
Maria Sueli S Felipe1, Fernando A G Torres, Andrea Q Maranhão, Ildinete Silva-Pereira, Marcio J Poças-Fonseca, Elida G Campos, Lídia M P Moraes, Fabrício B M Arraes, Maria José A Carvalho, Rosângela V Andrade, André M Nicola, Marcus M Teixeira, Rosália S A Jesuíno, Maristela Pereira, Célia M A Soares, Marcelo M Brígido.
Abstract
Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.Entities:
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Year: 2005 PMID： 16061364 DOI： 10.1016/j.femsim.2005.05.013
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244