| Literature DB >> 16056124 |
Sheng Xie1, Jiang Xi Xiao, Yin Hua Wang, Hong Kun Wu, Gao Lang Gong, Xue Xiang Jiang.
Abstract
A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative to normal controls, Alzheimer's disease patients showed a significant reduction of fractional anisotropy and hippocampal volumes. Significant correlation was observed between fractional anisotropy values and volumes of hippocampi and mini-mental state examination scores. This study suggests that lower anisotropy of cingulum bundles is associated with cognitive dysfunction and atrophy of the limbic system.Entities:
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Year: 2005 PMID: 16056124 DOI: 10.1097/01.wnr.0000174061.41897.ee
Source DB: PubMed Journal: Neuroreport ISSN: 0959-4965 Impact factor: 1.837