Literature DB >> 1605599

Pharmacokinetics and distribution over the blood brain barrier of two acyclic guanosine analogs in rats, studied by microdialysis.

L Ståhle1, B Oberg.   

Abstract

The free extracellular concentrations of acyclovir and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) in the blood and in brain tissue of rats were measured in microdialysis samples by high-pressure liquid chromatography with UV detection. The half-life of acyclovir in blood was 2 h, while that of H2G was 28 min. The concentration attained in the brain compared with the concentration in blood was slightly lower for H2G than for acyclovir. The results show that the pharmacokinetic profiles of acyclic nucleosides may vary as a consequence of the structure of the acyclic chain corresponding to the sugar moiety.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1605599      PMCID： PMC188438          DOI： 10.1128/AAC.36.2.339

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis.

Authors:  L Ståhle; S Segersvärd; U Ungerstedt
Journal:  J Pharmacol Methods       Date:  1991-03

Review 2.  Clinical pharmacokinetics of acyclovir.

Authors:  O L Laskin
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

3.  Theophylline concentration in the extracellular space of the rat brain: measurement by microdialysis and relation to behaviour.

Authors:  L Ståhle; S Segersvärd; U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1990-08-28       Impact factor: 4.432

4.  Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain and other tissues in rats.

Authors:  L Ståhle; S Segersvärd; U Ungerstedt
Journal:  Life Sci       Date:  1991       Impact factor: 5.037

5.  The disposition of acyclovir in different species.

Authors:  P de Miranda; H C Krasny; D A Page; G B Elion
Journal:  J Pharmacol Exp Ther       Date:  1981-11       Impact factor: 4.030

Review 6.  Azole antifungal agents: emphasis on new triazoles.

Authors:  M S Saag; W E Dismukes
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191
  6 in total
  8 in total

Review 1.  Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue.

Authors:  Markus Müller; Amparo dela Peña; Hartmut Derendorf
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

Review 2.  Application of microdialysis in pharmacokinetic studies.

Authors:  W F Elmquist; R J Sawchuk
Journal:  Pharm Res       Date:  1997-03       Impact factor: 4.200

3.  Microdialysis sampling to determine the pharmacokinetics of unbound SDZ ICM 567 in blood and brain in awake, freely-moving rats.

Authors:  M J Alonso; A Bruelisauer; P Misslin; M Lemaire
Journal:  Pharm Res       Date:  1995-02       Impact factor: 4.200

4.  Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2',3'-dideoxycytidine) and BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine) in rats, studied by microdialysis.

Authors:  N Borg; L Ståhle
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

5.  Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir.

Authors:  Jan Lycke; Clas Malmeström; Lars Ståhle
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

6.  Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis.

Authors:  L Granero; M Santiago; J Cano; A Machado; J E Peris
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

7.  Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells.

Authors:  Karen Yao; Christel Hoest; Farzin Rashti; Timm C Schott; Steven Jacobson
Journal:  J Clin Virol       Date:  2009-06-12       Impact factor: 3.168

8.  Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses.

Authors:  D M Lowe; W K Alderton; M R Ellis; V Parmar; W H Miller; G B Roberts; J A Fyfe; R Gaillard; P Ertl; W Snowden
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.