Literature DB >> 1605591

Simple assay to screen for inhibitors of interaction between the human immunodeficiency virus envelope glycoprotein and its cellular receptor, CD4.

V Chams1, T Idziorek, P J Maddon, D Klatzmann.   

Abstract

The binding of the human immunodeficiency virus envelope glycoprotein gp120 to the CD4 molecule is the initial step in the viral replicative cycle. This interaction is therefore an important target for therapeutic intervention for the treatment of human immunodeficiency virus infection. We designed an enzyme-linked immunosorbent assay which detects the interaction between recombinant soluble forms of CD4 and gp160. This assay could be used as an initial screen of libraries of synthetic chemical compounds and natural products.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1605591      PMCID： PMC188348          DOI： 10.1128/AAC.36.2.267

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4.

Authors:  J P Moore
Journal:  AIDS       Date:  1990-04       Impact factor: 4.177

2.  Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV).

Authors:  J S McDougal; S P Cort; M S Kennedy; C D Cabridilla; P M Feorino; D P Francis; D Hicks; V S Kalyanaraman; L S Martin
Journal:  J Immunol Methods       Date:  1985-01-21       Impact factor: 2.303

3.  Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.

Authors:  J S McDougal; J K Nicholson; G D Cross; S P Cort; M S Kennedy; A C Mawle
Journal:  J Immunol       Date:  1986-11-01       Impact factor: 5.422

4.  Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro.

Authors:  M Ito; M Baba; A Sato; R Pauwels; E De Clercq; S Shigeta
Journal:  Antiviral Res       Date:  1987-07       Impact factor: 5.970

Review 5.  Structure and function of the HIV envelope.

Authors:  J A McKeating; R L Willey
Journal:  AIDS       Date:  1989       Impact factor: 4.177

6.  A rapid and simple colorimetric test for the study of anti-HIV agents.

Authors:  O Schwartz; Y Henin; V Marechal; L Montagnier
Journal:  AIDS Res Hum Retroviruses       Date:  1988-12       Impact factor: 2.205

7.  Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.

Authors:  D Schols; M Baba; R Pauwels; J Desmyter; E De Clercq
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

8.  Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

Authors:  M Baba; R Pauwels; J Balzarini; J Arnout; J Desmyter; E De Clercq
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

9.  Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1.

Authors:  P S Linsley; J A Ledbetter; E Kinney-Thomas; S L Hu
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

10.  Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.

Authors:  H Mitsuya; D J Looney; S Kuno; R Ueno; F Wong-Staal; S Broder
Journal:  Science       Date:  1988-04-29       Impact factor: 47.728
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.