BACKGROUND: The extent to which antipsychotics improve patients' well-being is uncertain. AIMS: To examine psychopathology and patient-rated functioning and well-being in patients treated with risperidone. METHOD: In a 1-year, open-label, international multicentre trial of long-acting risperidone in 615 stable adult patients with schizophrenia, self-rated functioning and well-being were measured every 3 months using the Short Form 36-item questionnaire (SF-36). Psychopathology was quantified using the Positive and Negative Syndrome Scale (PANSS). RESULTS: Significant improvements were found on the SF-36 mental component summary score and vitality and social functioning scales. PANSS and mental component summary scores were moderately correlated. CONCLUSIONS: Patient-reported functioning and well-being appear to differ from investigator-rated psychotic symptoms. Patient-rated well-being should be assessed with symptoms to help measure treatment outcomes.
BACKGROUND: The extent to which antipsychotics improve patients' well-being is uncertain. AIMS: To examine psychopathology and patient-rated functioning and well-being in patients treated with risperidone. METHOD: In a 1-year, open-label, international multicentre trial of long-acting risperidone in 615 stable adult patients with schizophrenia, self-rated functioning and well-being were measured every 3 months using the Short Form 36-item questionnaire (SF-36). Psychopathology was quantified using the Positive and Negative Syndrome Scale (PANSS). RESULTS: Significant improvements were found on the SF-36 mental component summary score and vitality and social functioning scales. PANSS and mental component summary scores were moderately correlated. CONCLUSIONS:Patient-reported functioning and well-being appear to differ from investigator-rated psychotic symptoms. Patient-rated well-being should be assessed with symptoms to help measure treatment outcomes.
Authors: E Fakra; S Khalfa; D Da Fonseca; N Besnier; P Delaveau; J M Azorin; O Blin Journal: Psychopharmacology (Berl) Date: 2008-06-25 Impact factor: 4.530
Authors: Alex Hofer; Maria A Rettenbacher; Christian G Widschwendter; Georg Kemmler; Martina Hummer; W Wolfgang Fleischhacker Journal: Eur Arch Psychiatry Clin Neurosci Date: 2005-11-29 Impact factor: 5.270