BACKGROUND: The Early Detection and Intervention Programme of the German Research Network on Schizophrenia (GRNS) investigates the initial prodromal phase of psychosis in a multidimensional approach. Two intervention strategies are being studied by two large-scale multicentre projects. AIMS: To present the concept of the intervention studies, and to provide an interim report of the recruitment procedure. METHOD:Comprehensive cognitive-behavioural therapy has been developed for patients in the "early initial prodromal state". For patients in the "late initial prodromal state" the atypical neuroleptic amisulpride is explored. Both interventions are evaluated in randomised controlled trials using clinical management as the control condition. RESULTS:Between January 2001 and March 2003, 1212 individuals seeking help for mental health problems were screened for putative prodromal symptoms at four university centres. More than 388 individuals fulfilled criteria for both interventions and 188 (48.5%) gave informed consent to participate in the trials. CONCLUSIONS: The screening procedure appears to be feasible and trial participation seems to be acceptable to a relevant proportion of people at increased risk of developing psychosis.
RCT Entities:
BACKGROUND: The Early Detection and Intervention Programme of the German Research Network on Schizophrenia (GRNS) investigates the initial prodromal phase of psychosis in a multidimensional approach. Two intervention strategies are being studied by two large-scale multicentre projects. AIMS: To present the concept of the intervention studies, and to provide an interim report of the recruitment procedure. METHOD: Comprehensive cognitive-behavioural therapy has been developed for patients in the "early initial prodromal state". For patients in the "late initial prodromal state" the atypical neuroleptic amisulpride is explored. Both interventions are evaluated in randomised controlled trials using clinical management as the control condition. RESULTS: Between January 2001 and March 2003, 1212 individuals seeking help for mental health problems were screened for putative prodromal symptoms at four university centres. More than 388 individuals fulfilled criteria for both interventions and 188 (48.5%) gave informed consent to participate in the trials. CONCLUSIONS: The screening procedure appears to be feasible and trial participation seems to be acceptable to a relevant proportion of people at increased risk of developing psychosis.
Authors: Andreas Bechdolf; Lisa J Phillips; Shona M Francey; Steven Leicester; Anthony P Morrison; Verena Veith; Joachim Klosterkötter; Patrick D McGorry Journal: Eur Arch Psychiatry Clin Neurosci Date: 2006-04 Impact factor: 5.270
Authors: Thomas H McGlashan; Jean Addington; Tyrone Cannon; Markus Heinimaa; Patrick McGorry; Mary O'Brien; David Penn; Diana Perkins; Raimo K R Salokangas; Barbara Walsh; Scott W Woods; Alison Yung Journal: Schizophr Bull Date: 2007-05-04 Impact factor: 9.306
Authors: Wolfgang Wölwer; Jürgen Brinkmeyer; Sanna Stroth; Marcus Streit; Andreas Bechdolf; Stephan Ruhrmann; Michael Wagner; Wolfgang Gaebel Journal: Schizophr Bull Date: 2011-03-14 Impact factor: 9.306