BACKGROUND: Subtle motor, emotional, cognitive and behavioural abnormalities are often present in apparently healthy individuals who later develop schizophrenia, suggesting that some aspects of causation are established before overt psychosis. AIMS: To outline the development of schizophrenia. METHOD: We drew on evidence from The Northern Finland 1966 Birth Cohort supplemented by selected findings from other relevant literature. RESULTS: The main known risk factors in development of schizophrenia are genetic causes, pregnancy and delivery complications, slow neuromotor development, and deviant cognitive and academic performance. However, their effect size and predictive power are small. CONCLUSIONS: No powerful risk factor, premorbid sign or risk indicator has been identified that is useful for the prediction of schizophrenia in the general population.
BACKGROUND: Subtle motor, emotional, cognitive and behavioural abnormalities are often present in apparently healthy individuals who later develop schizophrenia, suggesting that some aspects of causation are established before overt psychosis. AIMS: To outline the development of schizophrenia. METHOD: We drew on evidence from The Northern Finland 1966 Birth Cohort supplemented by selected findings from other relevant literature. RESULTS: The main known risk factors in development of schizophrenia are genetic causes, pregnancy and delivery complications, slow neuromotor development, and deviant cognitive and academic performance. However, their effect size and predictive power are small. CONCLUSIONS: No powerful risk factor, premorbid sign or risk indicator has been identified that is useful for the prediction of schizophrenia in the general population.
Authors: Matti Isohanni; Jouko Miettunen; Pirjo Mäki; Graham K Murray; Khanum Ridler; Erika Lauronen; Kristiina Moilanen; Antti Alaräisänen; Marianne Haapea; Irene Isohanni; Elena Ivleva; Carol Tamminga; John McGrath; Hannu Koponen Journal: World Psychiatry Date: 2006-10 Impact factor: 49.548
Authors: Jason Schiffman; Emily Kline; Nicole D Jameson; Holger J Sorensen; Shana Dodge; Thomas Tsuji; Erik L Mortensen; Sarnoff A Mednick Journal: Schizophr Res Date: 2015-07-23 Impact factor: 4.939