OBJECTIVE: Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in patients with first-episode schizophrenia. METHOD: Magnetic resonance imaging scans were obtained from 14 inpatients at their first hospitalization for psychosis and 14 normal comparison subjects. Manual editing was undertaken to delineate postcentral, supramarginal, and angular gyri gray matter volumes. RESULTS: Group comparisons revealed that the left angular gyrus gray matter volume in patients was 14.8% less than that of the normal subjects. None of the other regions measured showed significant group volume or asymmetry differences. CONCLUSIONS: Patients with new-onset schizophrenia showed smaller left angular gyrus volumes than normal subjects, consistent with other studies showing parietal lobe volume abnormalities in schizophrenia. Angular gyrus pathology in first-episode patients suggests that the angular gyrus may be a neuroanatomical substrate for the expression of schizophrenia.
OBJECTIVE: Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in patients with first-episode schizophrenia. METHOD: Magnetic resonance imaging scans were obtained from 14 inpatients at their first hospitalization for psychosis and 14 normal comparison subjects. Manual editing was undertaken to delineate postcentral, supramarginal, and angular gyri gray matter volumes. RESULTS: Group comparisons revealed that the left angular gyrus gray matter volume in patients was 14.8% less than that of the normal subjects. None of the other regions measured showed significant group volume or asymmetry differences. CONCLUSIONS:Patients with new-onset schizophrenia showed smaller left angular gyrus volumes than normal subjects, consistent with other studies showing parietal lobe volume abnormalities in schizophrenia. Angular gyrus pathology in first-episode patients suggests that the angular gyrus may be a neuroanatomical substrate for the expression of schizophrenia.
Authors: B Crespo-Facorro; J Kim; N C Andreasen; R Spinks; D S O'Leary; H J Bockholt; G Harris; V A Magnotta Journal: Psychiatry Res Date: 2000-12-04 Impact factor: 3.222
Authors: Y Hirayasu; R W McCarley; D F Salisbury; S Tanaka; J S Kwon; M Frumin; D Snyderman; D Yurgelun-Todd; R Kikinis; F A Jolesz; M E Shenton Journal: Arch Gen Psychiatry Date: 2000-07
Authors: M Niznikiewicz; R Donnino; R W McCarley; P G Nestor; D V Iosifescu; B O'Donnell; J Levitt; M E Shenton Journal: Am J Psychiatry Date: 2000-03 Impact factor: 18.112
Authors: Robert W Buchanan; Alan Francis; Celso Arango; Karl Miller; David M Lefkowitz; Robert P McMahon; Patrick E Barta; Godfrey D Pearlson Journal: Am J Psychiatry Date: 2004-02 Impact factor: 18.112
Authors: Tejas S Bhojraj; Alan N Francis; Rajaprabhakaran Rajarethinam; Shaun Eack; Shreedhar Kulkarni; Konasale M Prasad; Debra M Montrose; Diana Dworakowski; Vaibhav Diwadkar; Matcheri S Keshavan Journal: Schizophr Res Date: 2009-10-17 Impact factor: 4.939
Authors: Richard Newton; Alice Rouleau; Anna-Greta Nylander; Jean-Yves Loze; Henrike K Resemann; Sara Steeves; Benedicto Crespo-Facorro Journal: NPJ Schizophr Date: 2018-10-15