OBJECTIVE: The authors sought to expand previous findings of vermal abnormalities in bipolar disorder patients. METHOD: Magnetic resonance imaging (MRI) morphometry was used to quantify vermal subregion volumes in 18 subjects with first-episode bipolar disorder, 21 subjects with multiple-episode bipolar disorder, and 32 healthy subjects. RESULTS: Vermal subregion V2 volume was significantly smaller in multiple-episode bipolar disorder subjects than in first-episode patients and healthy subjects. Vermal subregion V3 was significantly smaller in multiple-episode bipolar disorder subjects than in healthy subjects. CONCLUSIONS: These results suggest that posterior-inferior cerebellar vermal abnormalities are present in patients with multiple-episode bipolar disorder.
OBJECTIVE: The authors sought to expand previous findings of vermal abnormalities in bipolar disorderpatients. METHOD: Magnetic resonance imaging (MRI) morphometry was used to quantify vermal subregion volumes in 18 subjects with first-episode bipolar disorder, 21 subjects with multiple-episode bipolar disorder, and 32 healthy subjects. RESULTS: Vermal subregion V2 volume was significantly smaller in multiple-episode bipolar disorder subjects than in first-episode patients and healthy subjects. Vermal subregion V3 was significantly smaller in multiple-episode bipolar disorder subjects than in healthy subjects. CONCLUSIONS: These results suggest that posterior-inferior cerebellar vermal abnormalities are present in patients with multiple-episode bipolar disorder.
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Authors: Ann K Shinn; Youkyung S Roh; Caitlin T Ravichandran; Justin T Baker; Dost Öngür; Bruce M Cohen Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2017-07
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Authors: Fay Y Womer; Fei Wang; Lara G Chepenik; Jessica H Kalmar; Linda Spencer; Erin Edmiston; Brian P Pittman; R Todd Constable; Xenophon Papademetris; Hilary P Blumberg Journal: Bipolar Disord Date: 2009-11 Impact factor: 6.744