| Literature DB >> 16055332 |
Peter Ballard1, Robert H Bradbury, Laurent F A Hennequin, D Mark Hickinson, Paul D Johnson, Jason G Kettle, Teresa Klinowska, Remy Morgentin, Donald J Ogilvie, Annie Olivier.
Abstract
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.Entities:
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Year: 2005 PMID： 16055332 DOI： 10.1016/j.bmcl.2005.06.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823