| Literature DB >> 16055309 |
Laurent M Dejean1, Sonia Martinez-Caballero, Stephen Manon, Kathleen W Kinnally.
Abstract
Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed.Entities:
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Year: 2005 PMID： 16055309 DOI： 10.1016/j.bbadis.2005.07.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002