| Literature DB >> 16055231 |
D Roberton1, H Marshall, T M Nolan, E Sokal, J Díez-Domingo, C-E Flodmark, L Rombo, G Lewald, J de la Flor, J M Casanovas, J Verdaguer, J Marés, D Van Esso, I Dieussaert, M Stoffel.
Abstract
This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).Entities:
Mesh：
Substances：
Year: 2005 PMID： 16055231 DOI： 10.1016/j.vaccine.2005.06.003
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641