Literature DB >> 16054996

Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.

Markus H Kuehn1, John H Fingert, Young H Kwon.   

Abstract

Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.

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Year:  2005        PMID： 16054996     DOI： 10.1016/j.ohc.2005.04.002

Source DB:  PubMed          Journal:  Ophthalmol Clin North Am        ISSN： 0896-1549


  72 in total

Review 1.  Cellular and molecular biology of optineurin.

Authors:  Hongyu Ying; Beatrice Y J T Yue
Journal:  Int Rev Cell Mol Biol       Date:  2012       Impact factor: 6.813

2.  Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action.

Authors:  Grace C Shih; David J Calkins
Journal:  Expert Rev Ophthalmol       Date:  2012-04

3.  30 Hz-flicker mfERG in primary open-angle glaucoma patients : 30 Hz-flicker-mfERG in POAG.

Authors:  Margarita G Todorova; Anja M Palmowski-Wolfe; Selim Orguel; Josef Flammer
Journal:  Doc Ophthalmol       Date:  2006-08-30       Impact factor: 2.379

4.  Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.

Authors:  Wei Zhu; Oliver W Gramlich; Lauren Laboissonniere; Ankur Jain; Val C Sheffield; Jeffrey M Trimarchi; Budd A Tucker; Markus H Kuehn
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-06       Impact factor: 11.205

5.  A nicotinic acetylcholine receptor agonist prevents loss of retinal ganglion cells in a glaucoma model.

Authors:  Kazuhiro Iwamoto; Patrick Birkholz; Austin Schipper; David Mata; David M Linn; Cindy L Linn
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-02-24       Impact factor: 4.799

6.  Role of brimonidine in the treatment of clinically significant macular edema with ischemic changes in diabetic maculopathy.

Authors:  Parul Chawla Gupta; Sunandan Sood; Subina Narang; Parul Ichhpujani
Journal:  Int Ophthalmol       Date:  2013-11-10       Impact factor: 2.031

7.  Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth.

Authors:  Takahisa Koga; Xiang Shen; Jeong-Seok Park; Ye Qiu; Bum-Chan Park; Rajalekshmy Shyam; Beatrice Y J T Yue
Journal:  Am J Pathol       Date:  2009-12-03       Impact factor: 4.307

8.  Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.

Authors:  Min Zhao; Christopher J Destache; Sunny E Ohia; Catherine A Opere
Journal:  Neurochem Res       Date:  2009-12       Impact factor: 3.996

9.  Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells: Applications for the Study and Treatment of Optic Neuropathies.

Authors:  Jessica A Cooke; Jason S Meyer
Journal:  Curr Ophthalmol Rep       Date:  2015-08-07

10.  Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.

Authors:  Jia Hua Fang; Xing Hua Wang; Zhi Rong Xu; Fa Gang Jiang
Journal:  BMC Neurosci       Date:  2010-03-03       Impact factor: 3.288
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