| Literature DB >> 16054799 |
Hyung-Sik Kang1, Eun-Mi Kim, Sanggyu Lee, Suk-Ran Yoon, Toshihiko Kawamura, Young-Cheol Lee, Sangsoo Kim, Pyung-Keun Myung, San Ming Wang, Inpyo Choi.
Abstract
Natural killer (NK) cells develop from hematopoietic stem cells (HSCs) in the bone marrow. To understand the molecular regulation of NK cell development, serial analysis of gene expression (SAGE) was applied to HSCs, NK precursor (pNK) cells, and mature NK cells (mNK) cultured without or with OP9 stromal cells. From 170,464 total individual tags from four SAGE libraries, 35,385 unique genes were identified. A set of genes was expressed in a stage-specific manner: 15 genes in HSCs, 30 genes in pNK cells, and 27 genes in mNK cells. Among them, lipoprotein lipase induced NK cell maturation and cytotoxic activity. Identification of genome-wide profiles of gene expression in different stages of NK cell development affords us a fundamental basis for defining the molecular network during NK cell development.Entities:
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Year: 2005 PMID： 16054799 DOI： 10.1016/j.ygeno.2005.06.010
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736