| Literature DB >> 16054689 |
Denise Howe1, Teresa Bromidge.
Abstract
During normal B-lymphocyte development once cells pass the pro-B stage the transcription factor LEF-1, a key component of the Wnt/beta-catenin pathway, is down regulated. However studies have shown that B-cell chronic lymphocytic leukaemia (CLL) lymphocytes, which have a mature B-cell phenotype, still express abundant LEF-1. This study demonstrates that although LEF-1 mRNA is universally, highly expressed in B-CLL, expression of this gene is much lower or absent in the majority of low-grade B-cell non-Hodgkin's lymphoma (NHL). This suggests that there exist key differences in the activity of the Wnt/beta-catenin pathway between low-grade B-cell malignancies.Entities:
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Year: 2005 PMID： 16054689 DOI： 10.1016/j.leukres.2005.06.004
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156