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Literature DB >> 16054360

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

Chi-Wan Lee¹, Hong Cao, Kozi Ichiyama, Tariq M Rana.

Abstract

By performing RNA-targeted structure-activity relationship studies, we discovered a novel peptidomimetic containing squaryldiamide as a potential bioisostere replacement for guanidine that binds transactivation responsive RNA with high affinity.

Entities: Chemical Species

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Year: 2005 PMID： 16054360 DOI： 10.1016/j.bmcl.2005.06.077

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Macrosteres: The Deltic Guanidinium Ion.

Authors: Kenji Mishiro; Fanghao Hu; Daniel W Paley; Wei Min; Tristan H Lambert
Journal: European J Org Chem Date: 2016-03-14

Review 2. Role of Tat protein in HIV neuropathogenesis.

Authors: Wenxue Li; Guanhan Li; Joseph Steiner; Avindra Nath
Journal: Neurotox Res Date: 2009-03-21 Impact factor: 3.911

3. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA.

Authors: Matthew S Lalonde; Michael A Lobritz; Annette Ratcliff; Mastooreh Chamanian; Zafiria Athanassiou; Mudit Tyagi; Julian Wong; John A Robinson; Jonathan Karn; Gabriele Varani; Eric J Arts
Journal: PLoS Pathog Date: 2011-05-19 Impact factor: 6.823

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

1. Macrosteres: The Deltic Guanidinium Ion.

Review 2. Role of Tat protein in HIV neuropathogenesis.

3. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA.

Review 4. Targeting the HIV RNA genome: high-hanging fruit only needs a longer ladder.

5. Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria.

6. The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.