Converging on a general model of protein evolution.

The availability of high-throughput genomic databases that establish protein dispensability, expression and interaction networks enables rigorous tests of competing models of protein evolution. Recent research utilizing these new data sets shows that protein evolution is more complex than was previously thought. Several variables, including protein dispensability, expression, functional density, and genetic modularity, appear to have independent effects on the evolutionary rate of proteins, suggesting that proteomes have evolved via an assembly of selectional regimes. These results indicate that a general model of protein evolution will emerge as more functional genomic data from a diversity of organisms accumulate.