| Literature DB >> 16054245 |
Elena V Gazina1, David N Harrison, Meryem Jefferies, Heneu Tan, David Williams, David A Anderson, Steven Petrou.
Abstract
Picornavirus replication causes leakage of cytoplasmic K+ and an influx of Na+ and Ca2+. In this study, we have explored the possibility that a blockade of Ca2+ and Na+ influx would reduce rhinovirus production and/or release. The Ca2+-channel blockers, verapamil and diltiazem, as well as the blocker of Na+/H+ exchange and the epithelial Na+ channel, EIPA, inhibited both virus production and release. The effect on virus release was more pronounced than the effect on production, thus raising the possibility that rhinovirus release may serve as a target for antiviral agents. Unexpectedly, our results also showed that the antiviral activity of the Ca2+-channel blockers was not due to the block of Ca2+ influx. Similarly, the antiviral activity of EIPA appeared to be unrelated to the blockade of cellular Na+/H+ exchanger or the epithelial Na+ channel. Potential alternative mechanisms of the antiviral activity of these compounds are discussed.Entities:
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Year: 2005 PMID： 16054245 DOI： 10.1016/j.antiviral.2005.05.003
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970