| Literature DB >> 16054030 |
Nurhan Ozlü1, Martin Srayko, Kazuhisa Kinoshita, Bianca Habermann, Eileen T O'toole, Thomas Müller-Reichert, Natalie Schmalz, Arshad Desai, Anthony A Hyman.
Abstract
In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, we identify TPXL-1, a C. elegans protein that is the first characterized invertebrate ortholog of TPX2. We demonstrate that an essential role of TPXL-1 during mitosis is to activate and target Aurora A to microtubules. Our data suggest that this targeting stabilizes microtubules connecting kinetochores to the spindle poles. Thus, activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly.Entities:
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Year: 2005 PMID： 16054030 DOI： 10.1016/j.devcel.2005.07.002
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270