Literature DB >> 16052173

Population-specific patterns of linkage disequilibrium in the human 5q31 region.

G Luoni1, J Forton, M Jallow, E Sadighi Akha, F Sisay-Joof, M Pinder, N Hanchard, M Herbert, M Kimber, R Mott, J Hull, K Rockett, D Kwiatkowski.   

Abstract

Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.

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Year:  2005        PMID： 16052173     DOI： 10.1038/sj.gene.6364250

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  4 in total

1.  Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III.

Authors:  Neil Hanchard; Mahamadou Diakite; Oliver Koch; Brendan Keating; Margaret Pinder; Muminatou Jallow; Fatou Sisay-Joof; Anastasia Nijnik; Jonathan Wilson; Irina Udalova; Dominic Kwiatkowski; Kirk Rockett
Journal:  Immunogenetics       Date:  2006-04-28       Impact factor: 2.846

2.  A genome-wide association and replication study of blood pressure in Ugandan early adolescents.

Authors:  Swaib A Lule; Alexander J Mentzer; Benigna Namara; Allan G Muwenzi; Beatrice Nassanga; Dennison Kizito; Helen Akurut; Lawrence Lubyayi; Josephine Tumusiime; Christopher Zziwa; Florence Akello; Deept Gurdasani; Manjinder Sandhu; Liam Smeeth; Alison M Elliott; Emily L Webb
Journal:  Mol Genet Genomic Med       Date:  2019-08-30       Impact factor: 2.183

3.  Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

Authors:  Angels Natividad; Jeremy Hull; Gaia Luoni; Martin Holland; Kirk Rockett; Hassan Joof; Matthew Burton; David Mabey; Dominic Kwiatkowski; Robin Bailey
Journal:  BMC Med Genet       Date:  2009-12-16       Impact factor: 2.103

4.  Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster.

Authors:  J T Forton; K Rowlands; K Rockett; N Hanchard; M Herbert; D P Kwiatkowski; J Hull
Journal:  Thorax       Date:  2009-01-08       Impact factor: 9.139
  4 in total

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