| Literature DB >> 16051142 |
Abstract
The proposal that the transmissible agent in prion diseases can be a conformationally altered host protein that multiplies by autocatalytic conversion has gained wide acceptance. Recent work shows that the agent, the prion, can be replicated in a cell-free system, that it can be generated de novo, and that the strain-specific properties of prions are encoded by conformational variations of the underlying protein.Entities:
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Year: 2005 PMID： 16051142 DOI： 10.1016/j.cell.2005.07.001
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582