Literature DB >> 16051031

Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.

K Melancon1, Q Cheng, T L Kiefer, J Dai, L Lai, C Dong, L Yuan, A Collins, A Thiyagarajah, S Long, S M Hill.   

Abstract

A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30 mg/kg chow/day), melatonin 500 microg/day, melatonin 1000 microg/day, melatonin 500 microg/day+9cRA and melatonin 1000 microg/day+9cRA. Rats treated with the lower dose of melatonin 500 microg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.

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Year:  2005        PMID： 16051031     DOI： 10.1016/j.canlet.2005.01.005

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  7 in total

Review 1.  Melatonin: an inhibitor of breast cancer.

Authors:  Steven M Hill; Victoria P Belancio; Robert T Dauchy; Shulin Xiang; Samantha Brimer; Lulu Mao; Adam Hauch; Peter W Lundberg; Whitney Summers; Lin Yuan; Tripp Frasch; David E Blask
Journal:  Endocr Relat Cancer       Date:  2015-04-15       Impact factor: 5.678

2.  Evaluation of melatonin and AFMK levels in women with breast cancer.

Authors:  Tialfi Bergamin de Castro; Newton Antônio Bordin-Junior; Eduardo Alves de Almeida; Debora Aparecida Pires de Campos Zuccari
Journal:  Endocrine       Date:  2018-05-24       Impact factor: 3.633

3.  A combination of green tea extract, specific nutrient mixture and quercetin: An effective intervention treatment for the regression of N-methyl-N-nitrosourea (MNU)-induced mammary tumors in Wistar rats.

Authors:  Anup Kale; Sonia Gawande; Swati Kotwal; Shrirang Netke; M Waheed Roomi; Vadim Ivanov; Aleksandra Niedzwiecki; Matthias Rath
Journal:  Oncol Lett       Date:  2010-03-01       Impact factor: 2.967

4.  The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation.

Authors:  Ling Lai; Lin Yuan; Qi Chen; Chunmin Dong; Lulu Mao; Brian Rowan; Tripp Frasch; Steven M Hill
Journal:  J Pineal Res       Date:  2008-08-13       Impact factor: 13.007

5.  Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways.

Authors:  A E Zubidat; B Fares; F Fares; A Haim
Journal:  Cancer Control       Date:  2018 Jan-Dec       Impact factor: 3.302

6.  High Expression of Cyclin D1 and p21 in N-Nitroso-N-Methylurea-Induced Breast Cancer in Wistar Albino Female Rats.

Authors:  Mahboobeh Ashrafi; Seyedeh Zahra Bathaie; Saeid Abroun
Journal:  Cell J       Date:  2012-12-12       Impact factor: 2.479

7.  Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet.

Authors:  Natalia Kurhaluk; Halyna Tkachenko
Journal:  Sci Rep       Date:  2022-03-23       Impact factor: 4.379
  7 in total

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