| Literature DB >> 16050731 |
Francesca Cardona1, Guillermo Moreno, Francesco Guarna, Pierre Vogel, Catherine Schuetz, Pedro Merino, Andrea Goti.
Abstract
An efficient and concise total synthesis of (+)-lentiginosine (1) starting from an L-tartaric acid-derived nitrone using organometallic addition, indium-catalyzed reduction, and ring-closing metathesis reaction as the key steps is reported. Structural analogues of (+)-1 have been also synthesized, and their inhibitory activity toward 22 commercially available glycosidases has been evaluated.Entities:
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Year: 2005 PMID： 16050731 DOI： 10.1021/jo0509408
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354