| Literature DB >> 16050678 |
Regan J Anderson1, Jonathan B Hill, Jonathan C Morris.
Abstract
The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. In addition, the deoxygenated analogue was prepared in 6 steps and 23% overall yield, starting from the same starting material.Entities:
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Year: 2005 PMID： 16050678 DOI： 10.1021/jo050523v
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354