| Literature DB >> 16049942 |
Michèle Kujas1, Julie Lejeune, Alexandra Benouaich-Amiel, Emmanuelle Crinière, Florence Laigle-Donadey, Yannick Marie, Karima Mokhtari, Marc Polivka, Michèle Bernier, Fabrice Chretien, Anne Couvelard, Laurent Capelle, Hugues Duffau, Philippe Cornu, Philippe Broët, Joëlle Thillet, Antoine F Carpentier, Marc Sanson, Khê Hoang-Xuan, Jean-Yves Delattre.
Abstract
Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low-grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression-free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression-free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas.Entities:
Mesh：
Year: 2005 PMID： 16049942 DOI： 10.1002/ana.20543
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422