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Literature DB >> 16049480

Genes that mediate breast cancer metastasis to lung.

Andy J Minn¹, Gaorav P Gupta, Peter M Siegel, Paula D Bos, Weiping Shu, Dilip D Giri, Agnes Viale, Adam B Olshen, William L Gerald, Joan Massagué.

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

Entities: CellLine Disease Gene

Mesh：

Substances：
RNA, Neoplasm

Year: 2005 PMID： 16049480 PMCID： PMC1283098 DOI： 10.1038/nature03799

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

33 in total

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Journal: Breast Cancer Res Treat Date: 2000-02 Impact factor: 4.872

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Journal: J Clin Oncol Date: 2000-02 Impact factor: 44.544

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Journal: Carcinogenesis Date: 2000-03 Impact factor: 4.944

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Journal: In Vitro Date: 1978-11

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Authors: Y Yarden; M X Sliwkowski
Journal: Nat Rev Mol Cell Biol Date: 2001-02 Impact factor: 94.444

6. Genomic analysis of metastasis reveals an essential role for RhoC.

Authors: E A Clark; T R Golub; E S Lander; R O Hynes
Journal: Nature Date: 2000-08-03 Impact factor: 49.962

7. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.

Authors: Andy J Minn; Yibin Kang; Inna Serganova; Gaorav P Gupta; Dilip D Giri; Mikhail Doubrovin; Vladimir Ponomarev; William L Gerald; Ronald Blasberg; Joan Massagué
Journal: J Clin Invest Date: 2005-01 Impact factor: 14.808

8. Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression.

Authors: Ben Davidson; Sophya Konstantinovsky; Søren Nielsen; Hiep Phuc Dong; Aasmund Berner; Mogens Vyberg; Reuven Reich
Journal: Clin Cancer Res Date: 2004-11-01 Impact factor: 12.531

9. Molecular portraits of human breast tumours.

Authors: C M Perou; T Sørlie; M B Eisen; M van de Rijn; S S Jeffrey; C A Rees; J R Pollack; D T Ross; H Johnsen; L A Akslen; O Fluge; A Pergamenschikov; C Williams; S X Zhu; P E Lønning; A L Børresen-Dale; P O Brown; D Botstein
Journal: Nature Date: 2000-08-17 Impact factor: 49.962

10. Probabilities of death from breast cancer and other causes among female breast cancer patients.

Authors: Catherine Schairer; Pamela J Mink; Leslie Carroll; Susan S Devesa
Journal: J Natl Cancer Inst Date: 2004-09-01 Impact factor: 13.506

1303 in total

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Authors: Dan Guo; Jiayi Huang; Jianping Gong
Journal: Mol Cell Biochem Date: 2011-12-14 Impact factor: 3.396

2. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

Authors: Brian D Lehmann; Joshua A Bauer; Xi Chen; Melinda E Sanders; A Bapsi Chakravarthy; Yu Shyr; Jennifer A Pietenpol
Journal: J Clin Invest Date: 2011-07 Impact factor: 14.808

3. Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.

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Journal: J Biol Chem Date: 2011-06-02 Impact factor: 5.157

4. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

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Journal: Nat Cell Biol Date: 2018-07-23 Impact factor: 28.824

Review 5. Cancer stem cells and their role in metastasis.

Authors: Yusuke Shiozawa; Biao Nie; Kenneth J Pienta; Todd M Morgan; Russell S Taichman
Journal: Pharmacol Ther Date: 2013-02-04 Impact factor: 12.310

6. Serpins promote cancer cell survival and vascular co-option in brain metastasis.

Authors: Manuel Valiente; Anna C Obenauf; Xin Jin; Qing Chen; Xiang H-F Zhang; Derek J Lee; Jamie E Chaft; Mark G Kris; Jason T Huse; Edi Brogi; Joan Massagué
Journal: Cell Date: 2014-02-27 Impact factor: 41.582

7. Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences.

Authors: Siker Kimbung; Anikó Kovács; Pär-Ola Bendahl; Per Malmström; Mårten Fernö; Thomas Hatschek; Ingrid Hedenfalk
Journal: Mol Oncol Date: 2013-10-14 Impact factor: 6.603