| Literature DB >> 16048335 |
Dale E Ward1, Michael Santos Souweha.
Abstract
Thermal Diels-Alder reaction of 2,4-hexadienol with methyl acrylate is unselective. By simultaneous coordination of diene and dienophile to a chiral bimetallic Lewis acid catalyst, a LACASA-DA reaction occurs with complete control of regio-, diastereo-, and enantioselectivity to give a single adduct. [reaction: see text]Entities:
Year: 2005 PMID： 16048335 DOI： 10.1021/ol051262e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005