PURPOSE: To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI. METHODS: We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (< or = 35 and > 35 years) and the number of transferred embryos (1-3 and 4-9). RESULTS: Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9). CONCLUSION: Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.
PURPOSE: To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI. METHODS: We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (< or = 35 and > 35 years) and the number of transferred embryos (1-3 and 4-9). RESULTS: Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9). CONCLUSION: Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.
Authors: Richard P Dickey; Steven N Taylor; Peter Y Lu; Belinda M Sartor; John M Storment; Phillip H Rye; William D Pelletier; James L Zender; Ellen M Matulich Journal: Am J Obstet Gynecol Date: 2002-01 Impact factor: 8.661
Authors: Giovanni B La Sala; Giuseppe Nucera; Andrea Gallinelli; Alessia Nicoli; Maria Teresa Villani; Isaac Blickstein Journal: Am J Obstet Gynecol Date: 2004-09 Impact factor: 8.661
Authors: Giovanni B La Sala; Giuseppe Nucera; Andrea Gallinelli; Alessia Nicoli; Maria Teresa Villani; Isaac Blickstein Journal: Fertil Steril Date: 2004-12 Impact factor: 7.329
Authors: F Zegers-Hochschild; M Bravo; E Fernández; C Fabres; J P Balmaceda; A Mackenna Journal: Reprod Biomed Online Date: 2004-01 Impact factor: 3.828
Authors: János Urbancsek; Erik Hauzman; Péter Fedorcsák; Amrita Halmos; Nóra Dévényi; Zoltán Papp Journal: Fertil Steril Date: 2002-09 Impact factor: 7.329