Literature DB >> 16046164

Decoding Tat: the biology of HIV Tat posttranslational modifications.

Claudia Hetzer1, Wilma Dormeyer, Martina Schnölzer, Melanie Ott.   

Abstract

The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.

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Year:  2005        PMID: 16046164     DOI: 10.1016/j.micinf.2005.06.003

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  19 in total

Review 1.  Post-translationally modified T cell epitopes: immune recognition and immunotherapy.

Authors:  Jan Petersen; Anthony W Purcell; Jamie Rossjohn
Journal:  J Mol Med (Berl)       Date:  2009-09-08       Impact factor: 4.599

Review 2.  Genetic variation and function of the HIV-1 Tat protein.

Authors:  Cassandra Spector; Anthony R Mele; Brian Wigdahl; Michael R Nonnemacher
Journal:  Med Microbiol Immunol       Date:  2019-03-05       Impact factor: 3.402

3.  The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.

Authors:  Sara Pagans; Steven E Kauder; Katrin Kaehlcke; Naoki Sakane; Sebastian Schroeder; Wilma Dormeyer; Raymond C Trievel; Eric Verdin; Martina Schnolzer; Melanie Ott
Journal:  Cell Host Microbe       Date:  2010-03-18       Impact factor: 21.023

4.  Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription.

Authors:  Qi Wang; Tara M Young; Michael B Mathews; Tsafi Pe'ery
Journal:  J Mol Biol       Date:  2007-01-12       Impact factor: 5.469

5.  Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.

Authors:  Sungyoo Cho; Sebastian Schroeder; Katrin Kaehlcke; Hye-Sook Kwon; Angelika Pedal; Eva Herker; Martina Schnoelzer; Melanie Ott
Journal:  EMBO J       Date:  2009-04-23       Impact factor: 11.598

6.  Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures.

Authors:  Michael Y Aksenov; Marina V Aksenova; Charles F Mactutus; Rosemarie M Booze
Journal:  Exp Neurol       Date:  2009-07-15       Impact factor: 5.330

7.  Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.

Authors:  Haran Sivakumaran; Armando van der Horst; Alex J Fulcher; Ann Apolloni; Min-Hsuan Lin; David A Jans; David Harrich
Journal:  J Virol       Date:  2009-09-02       Impact factor: 5.103

8.  Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.

Authors:  Minghao He; Linlin Zhang; Xincheng Wang; Lihong Huo; Lei Sun; Chengye Feng; Xutian Jing; Danyao Du; Huabin Liang; Min Liu; Zhangyong Hong; Jun Zhou
Journal:  PLoS One       Date:  2013-06-27       Impact factor: 3.240

9.  In vitro nuclear interactome of the HIV-1 Tat protein.

Authors:  Virginie W Gautier; Lili Gu; Niaobh O'Donoghue; Stephen Pennington; Noreen Sheehy; William W Hall
Journal:  Retrovirology       Date:  2009-05-19       Impact factor: 4.602

10.  Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.

Authors:  Nicolas Charnay; Roland Ivanyi-Nagy; Ricardo Soto-Rifo; Théophile Ohlmann; Marcelo López-Lastra; Jean-Luc Darlix
Journal:  Retrovirology       Date:  2009-08-11       Impact factor: 4.602

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