BACKGROUND: Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin-10 (IL-10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL-10 contains single nucleotide polymorphisms and 2 polymorphic microsatellites in the 5'-flanking region. Our aim was to ascertain if any of these polymorphic markers is associated with IBD among Spanish patients. METHODS: We genotyped 470 patients with IBD, 242 with ulcerative colitis and 228 with Crohn's disease (CD), and 572 ethnically matched controls for microsatellites IL-10R and IL-10G and 2 single nucleotide polymorphisms at positions -1082 and -819 in the proximal promoter of the gene. RESULTS: IL-10G14 microsatellite allele as well as -1082G allele were significantly increased in patients with CD. The combined presence of both alleles in 1 individual notably increased the risk to develop CD (P = 0.00006, odds ratio = 3.18). CONCLUSION: IL-10 polymorphisms contribute to susceptibility to CD in Spanish population.
BACKGROUND:Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin-10 (IL-10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL-10 contains single nucleotide polymorphisms and 2 polymorphic microsatellites in the 5'-flanking region. Our aim was to ascertain if any of these polymorphic markers is associated with IBD among Spanish patients. METHODS: We genotyped 470 patients with IBD, 242 with ulcerative colitis and 228 with Crohn's disease (CD), and 572 ethnically matched controls for microsatellites IL-10R and IL-10G and 2 single nucleotide polymorphisms at positions -1082 and -819 in the proximal promoter of the gene. RESULTS: IL-10G14 microsatellite allele as well as -1082G allele were significantly increased in patients with CD. The combined presence of both alleles in 1 individual notably increased the risk to develop CD (P = 0.00006, odds ratio = 3.18). CONCLUSION:IL-10 polymorphisms contribute to susceptibility to CD in Spanish population.
Authors: Concepción Núñez; Diana Alecsandru; Jezabel Varadé; Isabel Polanco; Carlos Maluenda; Miguel Fernández-Arquero; Emilio G de la Concha; Elena Urcelay; Alfonso Martínez Journal: BMC Med Genet Date: 2006-03-31 Impact factor: 2.103
Authors: Vibeke Andersen; Anja Ernst; Jane Christensen; Mette Østergaard; Bent A Jacobsen; Anne Tjønneland; Henrik B Krarup; Ulla Vogel Journal: BMC Med Genet Date: 2010-05-28 Impact factor: 2.103
Authors: Juan L Mendoza; Elena Urcelay; Raquel Lana; Alfonso Martinez; Carlos Taxonera; Emilio G de la Concha; Manuel Díaz-Rubio Journal: World J Gastroenterol Date: 2006-01-21 Impact factor: 5.742
Authors: Javier Ortiz; Miguel Fernández-Arquero; Elena Urcelay; Raquel López-Mejías; Antonio Ferreira; Gumersindo Fontán; Emilio G de la Concha; Alfonso Martínez Journal: BMC Med Genet Date: 2006-06-27 Impact factor: 2.103