| Literature DB >> 16043709 |
Barbara A Methé1, Karen E Nelson, Jody W Deming, Bahram Momen, Eugene Melamud, Xijun Zhang, John Moult, Ramana Madupu, William C Nelson, Robert J Dodson, Lauren M Brinkac, Sean C Daugherty, Anthony S Durkin, Robert T DeBoy, James F Kolonay, Steven A Sullivan, Liwei Zhou, Tanja M Davidsen, Martin Wu, Adrienne L Huston, Matthew Lewis, Bruce Weaver, Janice F Weidman, Hoda Khouri, Terry R Utterback, Tamara V Feldblyum, Claire M Fraser.
Abstract
The completion of the 5,373,180-bp genome sequence of the marine psychrophilic bacterium Colwellia psychrerythraea 34H, a model for the study of life in permanently cold environments, reveals capabilities important to carbon and nutrient cycling, bioremediation, production of secondary metabolites, and cold-adapted enzymes. From a genomic perspective, cold adaptation is suggested in several broad categories involving changes to the cell membrane fluidity, uptake and synthesis of compounds conferring cryotolerance, and strategies to overcome temperature-dependent barriers to carbon uptake. Modeling of three-dimensional protein homology from bacteria representing a range of optimal growth temperatures suggests changes to proteome composition that may enhance enzyme effectiveness at low temperatures. Comparative genome analyses suggest that the psychrophilic lifestyle is most likely conferred not by a unique set of genes but by a collection of synergistic changes in overall genome content and amino acid composition.Entities:
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Year: 2005 PMID： 16043709 PMCID： PMC1180510 DOI： 10.1073/pnas.0504766102
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205