OBJECTIVE: The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. METHOD: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non-IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. RESULT: During the study period there were 48 deliveries to patients with Crohn's disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (<37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR)=2.2; 95% confidence interval (CI)=1.3-3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel-Haenszel technique (weighted OR=2.1; 95% CI 1.3-3.5 and weighted OR=2.0; 95% CI 1.2-3.5; P=0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR=2.2; 95% CI=1.1-4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR=2.0; 95% CI=1.2-3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. CONCLUSION: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.
OBJECTIVE: The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. METHOD: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non-IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. RESULT: During the study period there were 48 deliveries to patients with Crohn's disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (<37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR)=2.2; 95% confidence interval (CI)=1.3-3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel-Haenszel technique (weighted OR=2.1; 95% CI 1.3-3.5 and weighted OR=2.0; 95% CI 1.2-3.5; P=0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR=2.2; 95% CI=1.1-4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR=2.0; 95% CI=1.2-3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. CONCLUSION: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.
Authors: Adeline Germain; Thomas Chateau; Laura Beyer-Berjot; Philippe Zerbib; Zaher Lakkis; Aurélien Amiot; Anthony Buisson; David Laharie; Jérémie H Lefèvre; Stéphane Nancey; Carmen Stefanescu; Laurent Bresler; Laurent Peyrin-Biroulet Journal: United European Gastroenterol J Date: 2020-04-23 Impact factor: 4.623
Authors: Stefano Palomba; Giuliana Sereni; Angela Falbo; Marina Beltrami; Silvia Lombardini; Maria Chiara Boni; Giovanni Fornaciari; Romano Sassatelli; Giovanni Battista La Sala Journal: World J Gastroenterol Date: 2014-06-21 Impact factor: 5.742
Authors: Alison de Lima-Karagiannis; Zuzana Zelinkova-Detkova; Christien Janneke van der Woude Journal: Am J Gastroenterol Date: 2016-06-28 Impact factor: 10.864