BACKGROUND: A key to successful adaptation is the ability to regulate emotional responses in relation to changing environmental demands or contexts. METHODS: High-resolution PET 18fluoro-deoxyglucose (FDG) scanning in rhesus monkeys was performed during two contexts (alone, and human intruder with no eye contact) during which the duration of anxiety related freezing behavior was assessed. Correlations between individual differences in freezing duration and brain activity were performed for each of the two conditions, as well as for the contextual regulation between the two conditions. RESULTS: In both conditions, activity in the basal forebrain, including the bed nucleus of the stria terminalis and the nucleus accumbens were correlated with individual differences in freezing duration. In contrast, individual differences in the ability to regulate freezing behavior between contexts were correlated with activity in the dorsal anterior cingulate cortex, the thalamus and the dorsal raphe nucleus. CONCLUSIONS: These findings demonstrate differences in the neural circuitry mediating the expression compared to the contextual regulation of freezing behavior. These findings are relevant since altered regulatory processes may underlie anxiety disorders.
BACKGROUND: A key to successful adaptation is the ability to regulate emotional responses in relation to changing environmental demands or contexts. METHODS: High-resolution PET 18fluoro-deoxyglucose (FDG) scanning in rhesus monkeys was performed during two contexts (alone, and human intruder with no eye contact) during which the duration of anxiety related freezing behavior was assessed. Correlations between individual differences in freezing duration and brain activity were performed for each of the two conditions, as well as for the contextual regulation between the two conditions. RESULTS: In both conditions, activity in the basal forebrain, including the bed nucleus of the stria terminalis and the nucleus accumbens were correlated with individual differences in freezing duration. In contrast, individual differences in the ability to regulate freezing behavior between contexts were correlated with activity in the dorsal anterior cingulate cortex, the thalamus and the dorsal raphe nucleus. CONCLUSIONS: These findings demonstrate differences in the neural circuitry mediating the expression compared to the contextual regulation of freezing behavior. These findings are relevant since altered regulatory processes may underlie anxiety disorders.
Authors: Michel Barrot; Jocelien D A Olivier; Linda I Perrotti; Ralph J DiLeone; Olivier Berton; Amelia J Eisch; Soren Impey; Daniel R Storm; Rachael L Neve; Jerry C Yin; Venetia Zachariou; Eric J Nestler Journal: Proc Natl Acad Sci U S A Date: 2002-08-06 Impact factor: 11.205
Authors: Christopher A Corcoran; Peter J Pierre; Tyler Haddad; Christina Bice; Stephen J Suomi; Kathleen A Grant; David P Friedman; Allyson J Bennett Journal: Dev Psychobiol Date: 2011-11-09 Impact factor: 3.038
Authors: Terrence R Oakes; Andrew S Fox; Tom Johnstone; Moo K Chung; Ned Kalin; Richard J Davidson Journal: Neuroimage Date: 2006-11-20 Impact factor: 6.556
Authors: Arthur L Brody; Mark A Mandelkern; Richard E Olmstead; Jennifer Jou; Emmanuelle Tiongson; Valerie Allen; David Scheibal; Edythe D London; John R Monterosso; Stephen T Tiffany; Alex Korb; Joanna J Gan; Mark S Cohen Journal: Biol Psychiatry Date: 2007-01-09 Impact factor: 13.382
Authors: A J Shackman; A S Fox; J A Oler; S E Shelton; T R Oakes; R J Davidson; N H Kalin Journal: Mol Psychiatry Date: 2016-08-30 Impact factor: 15.992